: In the development of location-based social networks (LBSNs), spatial items have recommended and that has become an important way of helping users discover interesting locations to increase their engagement with location-based services. Although human movement exhibits sequential patterns in LBSNs, most current studies on spatial item recommendations do not consider the sequential influence of locations. we propose a sequential personalized spatial item recommendation framework (SPORE) which introduces a novel latent variable topic-region to model and fuse sequential influence with personal interest in the latent and exponential space. The advantages of modeling the sequential effect at the topic-region level include a significantly reduced prediction space, an effective alleviation of data sparsity and a direct expression of the semantic meaning of users’ spatial activities. We evaluate the performance of SPORE on two real datasets and one large-scale synthetic dataset. The results demonstrate a significant improvement in SPORE’s ability to recommend spatial items, in terms of both effectiveness and efficiency, compared with the state-of-the-art methods