Today, a large number of x-ray images are interpreted in hospitals and computer-aided system that can perform some intelligent task and analysis is needed in order to raise the accuracy and bring down the miss rate in hospitals, particularly when it comes to diagnosis of hairline fractures and fissures in bone joints. This research considered some segmentation techniques that have been used in the processing and analysis of medical images and a system design was proposed to efficiently compare these techniques. The designed system was tested successfully on a hand X-ray image which led to the proposal of simple techniques to eliminate intrinsic properties of x-ray imaging systems such as noise. The performance and accuracy of image segmentation techniques in bone structures were compared and these eliminated time wasting on the choice of image segmentation algorithms. Although there are several practical applications of image segmentation such as content-based image retrieval, machine vision, medical imaging, object detection, recognition tasks, etc., this study focuses on the performance comparison of several image segmentation techniques for medical X-ray images.